Publications

Bouhifd, M. et al. Quality assurance of metabolomics. ALTEX 32, 319-326 (2015).
http://www.ncbi.nlm.nih.gov/pubmed/26536290

Buick, J.K. et al. Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen 56, 520-534 (2015). 
http://www.ncbi.nlm.nih.gov/pubmed/25733247

Fasani, R.A. et al. The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium. Front Pharmacol 6, 322 (2015). http://www.ncbi.nlm.nih.gov/pubmed/26924983

Li, H.H. et al. Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells. Environ Mol Mutagen 56, 505-519 (2015). http://www.ncbi.nlm.nih.gov/pubmed/25733355

Moffat, I. et al. Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol 45, 1-43 (2015). http://www.ncbi.nlm.nih.gov/pubmed/25605026

Vantangoli, M.M., Madnick, S.J., Huse, S.M., Weston, P. & Boekelheide, K. MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels. PLoS One 10, e0135426 (2015). 
http://www.ncbi.nlm.nih.gov/pubmed/26267486

Maertens, A. et al. Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis. Arch Toxicol (2016). http://www.ncbi.nlm.nih.gov/pubmed/27039105

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ, Li H, Livi CB, Madnick S, Maertens A, Zhao L, Rosenberg M, Yager JD, Hartung T: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function. Nature Scientific Reports 2016 (in press)

Bouhifd, M., Andersen, M.E., Baghdikian, C., Boekelheide, K., Crofton, K.M., Fornace, A.J., Jr., Kleensang, A., Li, H., Livi, C., Maertens, A., McMullen, P.D., Rosenberg, M., Thomas, R., Vantangoli, M., Yager, J.D., Zhao, L., Hartung, T., 2015. The human toxome project. ALTEX 32, 112-124.
http://altweb.jhsph.edu/altex/32_2/Bouhifd.pdf

Bouhifd M, Hogberg HT, Kleensang A, Maertens A, Zhao L, Hartung T. 2014. Mapping the human toxome by systems toxicology. Basic & Clinical Pharmacology & Toxicology 115:24-31. doi: 10.1111/bcpt.12198 http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12198/abstract

Kleensang A, Maertens A, Rosenberg M, FitzpatrickS, Lamb J, Auerbach S, et al. t4 workshop report: Pathways of Toxicity. ALTEX. 2013. t4 Workshop Report: Pathways of Toxicity. Altex 31:53-61. doi: 10.14573/altex.1309261
http://www.altex.ch/resources/altex_2014_1_053_061_T4Kleensang1.pdf

Hartung T, van Vliet E, Jaworska J, Bonilla L, Skinner N and Thomas R. Food for thought… systems toxicology. ALTEX 2012, 29: 119-128.
http://altweb.jhsph.edu/altex/29_2/FFTHartung.pdf

Bouhifd M, Hartung T, Hogberg HT, Kleensang A and Zhao L. Review: Toxicometabolomics. J. Appl. Toxicol. 2013 May 30. doi: 10.1002/jat.2874.
http://caat.jhsph.edu/media/Bouhifd_2013_Review_Toxicometabo.pdf

Hartung T, Luechtefeld T, Maertens A and Kleensang A. Food for thought…Integrated Testing Strategies for Safety Assessments. ALTEX 2013, 30: 3-18
http://altweb.jhsph.edu/altex/30_1/FFTHartung.pdf

Hartung T. Pathways of Toxicity Mapping Center (PoToMaC). In: Spielmann H and Seidle T. Alternative Testing Strategies: Progress Report 2012 & AXLR8-3 Workshop Report on a “Roadmap to Next Generation Safety Testing Under Horizon 2020.” 165-169.
http://axlr8.eu/assets/axlr8-progress-report-2012.pdf

Ramirez T , Daneshian M, et. al. t4 Metabolomics in Toxicology and Preclinical Research. ALTEX 2013;30:(2): 209-225.
http://caat.jhsph.edu/media/Ramirez-ALTEX-2013.pdf

Manuscripts in Preparation or Review

Pendse, S.N. et al. Information-dependent Enrichment Analysis Reveals Time-dependent Transcriptional Regulation of the Estrogen Pathway of Toxicity. Arch Toxicol (2016) (in review)      

Chen, R.X. et al. Estrogenic transcriptional responses by metal toxicants (in preparation)